Shortly after the switch, she developed painful red plaques on her face and neck along with a mild fever. Doctors considered allergic reactions, lupus, and infections, but blood tests were largely normal. The new inhaler was stopped as a precaution while further evaluation continued.
“The results provided a definitive answer: Sweet syndrome.” This rare inflammatory disorder causes sudden painful skin lesions and fever due to an abnormal immune response. While it is sometimes linked to infections or medications, association with inhaled therapies is extremely uncommon, raising questions about possible systemic effects.
The patient was treated with corticosteroids, leading to rapid improvement within two days as symptoms resolved. The case highlights the importance of monitoring new medications closely, recognizing unusual reactions early, and considering rare diagnoses when symptoms do not follow typical patterns, especially after treatment changes.
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